NanoViricide’s EKC Eye Drug Candidate Stopped Clinical Conjunctivitis Pathology
2008-07-14 06:14:00
NanoViricide’s EKC Eye Drug Candidate Stopped Clinical Conjunctivitis Pathology
Statistical Data Analysis Revealed Excellent Efficacy Using Clinical
Scores in Animal Study; Confirmed Photographic Findings
WEST HAVEN, Conn.–(EMWNews)–NanoViricides, Inc. (OTC BB: NNVC.OB)
(the “Company”)
reported today that excellent efficacy of its EKC-Cide™
nanoviricide drug candidate was revealed upon statistical analyses of
clinical scores from the first animal study.
The EKC-Cide drug candidate clearly demonstrated prevention of
conjunctival injection (redness, dilation and prominence of the
conjunctival blood vessels) and blepharitis (crusting, discharge and
inflammation of the eyelid margins) using mathematical clinical scores
calculations. These data confirmed the excellent clinical response
observed earlier in eye photographs. In contrast, the control group
which received an inactive drop preparation (“negative
control”) displayed statistically significant
higher clinical scores consistent with the expected strong progression
of infection.
A rapid clinical response to the EKC-Cide treatment was also revealed by
these data, confirming earlier photograph observations. Substantial
differences in clinical scores, demonstrating clear prevention of
serious infection and improvement upon treatment, were observed within
three days after treatment. Moreover, while both scored parameters
(conjunctivitis and blepharitis) were still significantly elevated even
at day 10 in the “negative control”
group; in the EKC-Cide treated group both parameters had returned to
normal already at day 7, indicating full recovery.
These clinical scores were based on daily observations and recording of
the animals by trained observers. Further biological analyses are in
progress.
“These results confirm our earlier preliminary
photographic evidence,” said Eugene Seymour,
MD, MPH, CEO of the Company, adding, “We now
know that EKC-Cide efficacy is substantially superior to that of other
drugs in development against EKC.”
The Company has previously posted
photos on its website which demonstrated the rapid response to
treatment using the Company’s nanoviricide
drug candidate against Epidemic Kerato-Conjunctivitis (EKC) (http://www.nanoviricides.com/action_small_EKC_2008-06-09.html).
“EKC-Cide may have efficacy against other
viral conjunctivitis as well,” said Anil R.
Diwan, Ph.D., President of the Company, “It
uses a broad-spectrum ligand for finding the virus. Binding sites for
this ligand may be present on a large number of viruses.”
The Company plans to evaluate this broad-spectrum eye-drop formulation
against other viruses that cause eye diseases such as herpes simplex
virus (HSV).
The Company has previously reported that it is in talks with certain
pharmaceutical companies regarding potential licensing of a nanoviricide
against adenoviral EKC.
The two clinical scores employed were for “conjunctival
injection” i.e. redness and dilation or
prominence of conjunctival blood vessels, and for “blepharitis”
i.e. crusting, discharge and inflammation of eyelid margins. Both are
classic signs of pathological infection.
While the Company currently has no approved product for the treatment of
EKC and viral conjunctivitis, the treatment and prophylaxis market for
these classes of eye disease is expected to be of the order of several
billion dollars annually.
EKC is a highly contagious and very severe inflammation of the eyes that
results in disabling red eyes, discharge and inflammation of the eyelids
with clinical symptoms lasting several weeks. Bacterial conjunctivitis
may be treated with antibiotics; however, there is no treatment
currently available for viral EKC. Further, viral EKC, in some cases,
may result in the formation of hazy spots in the cornea called “sub-epithelial
infiltrates” which cause blurriness of
vision, a condition that may last up to two years.
About NanoViricides:
NanoViricides, Inc. (www.nanoviricides.com)
is a development stage company that is creating special purpose
nanomaterials for viral therapy. The Company’s novel nanoviricide™
class of drug candidates are designed to specifically attack enveloped
virus particles and to dismantle them. The Company is developing drugs
against a number of viral diseases including H5N1 bird flu, seasonal
influenza, HIV, EKC, hepatitis C, rabies, dengue fever, and Ebola virus,
among others.
This press release contains forward-looking statements that reflect the
Company’s current expectation regarding future events. Forward-looking
statements involve risks and uncertainties. Actual events could differ
materially and substantially from those projected herein and depend on a
number of factors. Certain statements in this release, and other written
or oral statements made by NanoViricides, Inc. are “forward-looking
statements” within the meaning of Section 27A
of the Securities Act of 1933 and Section 21E of the Securities Exchange
Act of 1934. These forward looking statements are subject to known and
unknown risks, uncertainties and other factors that may cause actual
results, performance, or achievements of the company to be different
from those expressed or implied including the success of the Company’s
research and development efforts, the availability of adequate
financing, the successful and timely completion of clinical studies and
the uncertainties related to the regulatory process, described in the “Management’s
Discussion and Analysis” section of the
Company’s Form 10-KSB and other reports and
filings with the Securities and Exchange Commission.
NanoViricides, Inc. |
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