Lorus Therapeutics Announces the Identification of a Potential Novel Biomarker in Patient Samples From a Clinical Trial of LOR-2040 Combined With Capecitabine in Breast Cancer
Link found between Skp2 and the target of LOR-2040, R2
TORONTO, ONTARIO–(EMWNews – Aug. 20, 2008) – Lorus Therapeutics Inc, (TSX:LOR)(AMEX:LRP) (“Lorus”), a biopharmaceutical company specializing in the research and development of pharmaceutical products and technologies for the management of cancer, today announced publication by the California Cancer Consortium of a paper entitled “Identification of F-box/LLR-repeated Protein 17 a Potential Useful Biomarker for Breast Cancer Therapy” (Xiao et al. Cancer Genomics and Proteomics 2008; 5: 151-160). This presents results of proteomics studies from a clinical trial of LOR-2040 in combination with Capecitabine in patients with advanced metastatic breast cancer.
“This study identified a relationship between the activity of the investigational anticancer drug LOR-2040 and its target, RRM2, also known as R2, and a protein identified now as Skp2, or FBXL17. Skp2 serves as a possible determinant of drug activity and resistance, which may present significant interest for future breast cancer research”, said Dr. Yen, who is Associate Director for Translational Research and Director of Clinical and Molecular Pharmacology at the Comprehensive Cancer Center at City of Hope. “This proteomics analysis approach represents a valuable new tool for identifying useful biomarkers to help explain the activity of specific cancer drugs”.
The primary author, Dr. Gary Guishan Xiao, and Dr. Yun Yen who directed these proteomics studies, carried out this research at City of Hope National Medical Center in Duarte California as part of the ongoing exploratory clinical investigation led by Dr. Helen Chew of the same institution with the sponsorship of the National Cancer Institute (NCI) Cancer Therapy Evaluation Program (CTEP). Lorus is collaborating in this program with the Division of Cancer Treatment and Diagnosis, NCI on the development of LOR-2040 under a Clinical Trials Agreement.
LOR-2040 (formerly GTI-2040) is an RNA-targeted drug that specifically targets the R2 component of ribonucleotide reductase, which is required for DNA synthesis and cell proliferation. Through downregulation of R2, LOR-2040 has demonstrated strong antitumor and antimetastatic activity in a variety of tumor types in both in vivo and in vitro models and is under study in a multiple Phase I/II clinical program, including an advanced Phase II clinical trial with LOR-2040 and high dose Ara-C (HiDAC) in refractory and relapsed Acute Myeloid Leukemia (AML). The R2 target has been described as a malignant determinant that is elevated in a wide range of tumors, which can cooperate with a variety of cellular cancer causing genes known as oncogenes to enhance tumor growth and metastatic potential.
Lorus is a biopharmaceutical company focused on the research and development of novel therapeutics in cancer. Lorus’ goal is to capitalize on its research, preclinical, clinical and regulatory expertise by developing new drug candidates that can be used, either alone, or in combination with other drugs, to successfully manage cancer. Through its own discovery efforts and an acquisition and in-licensing program, Lorus is building a portfolio of promising anticancer drugs. Lorus Therapeutics Inc. is listed on the Toronto Stock Exchange under the symbol LOR, and on the American Stock Exchange under the symbol LRP.
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Lorus Therapeutics Inc.’s recent press releases are available through the Company’s website at www.lorusthera.com. For Lorus’ regulatory filings on SEDAR, please go to www.Sedar.com. For SEDAR filings prior to July 10, 2007 you will find these under the company profile for Global Summit Real Estate Inc. (Old Lorus).
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